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Brain-Derived Neurotrophic Factor

Definition

Brain-Derived Neurotrophic Factor (BNDF) is a protein that helps existing neurons survive and encourages the growth of new nerves. An increase in BDNF helps with overall cognitive function, including with learning and memory. 

Mechanisms

Synaptic Plasticity

  • BDNF increases synaptic plasticity, which is the brain’s ability to strengthen or weaken synapses (connections between neurons) based on activity – essential for learning, memory formation, and the brain’s ability to adapt to new information

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Neurogenesis

  • BNDF increases neurogenesis (particularly in the hippocampus) - the process of generating new neurons

  • Supports cognitive flexibility and emotional resilience 

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Cell Survival and Neuroprotection

  • BNDF supports the survival of neurons and protects them from apoptosis (programmed cell death) – critical for maintaining a healthy nervous system and longevity

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