
Brain-Derived Neurotrophic Factor
Definition
Brain-Derived Neurotrophic Factor (BNDF) is a protein that helps existing neurons survive and encourages the growth of new nerves. An increase in BDNF helps with overall cognitive function, including with learning and memory.
Mechanisms
Synaptic Plasticity
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BDNF increases synaptic plasticity, which is the brain’s ability to strengthen or weaken synapses (connections between neurons) based on activity – essential for learning, memory formation, and the brain’s ability to adapt to new information
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Neurogenesis
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BNDF increases neurogenesis (particularly in the hippocampus) - the process of generating new neurons
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Supports cognitive flexibility and emotional resilience
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Cell Survival and Neuroprotection
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BNDF supports the survival of neurons and protects them from apoptosis (programmed cell death) – critical for maintaining a healthy nervous system and longevity